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Efficacy and safety of MAS062D moisturizer lotion versus hydrophilic cream in improving the skin moisturization and skin barrier function and in xerosis in the elderly : A split site, double-blinded, Randomized, controlled trial |
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| รหัสดีโอไอ | |
| Title | Efficacy and safety of MAS062D moisturizer lotion versus hydrophilic cream in improving the skin moisturization and skin barrier function and in xerosis in the elderly : A split site, double-blinded, Randomized, controlled trial |
| Creator | Soktepy Bith |
| Contributor | Suparuj Lueangarun, Advisor |
| Publisher | Thammasat University |
| Publication Year | 2560 |
| Keyword | Xerosis, Moisturizers, Anti-inflammation, Moisturizer with anti-inflammatory ingredient, Treatment |
| Abstract | Xerosis is very common problem in elderly characterized by erythema, dry scaling or fissuring and either the presence or absence of pruritus which could be treated by moisturizer with anti-inflammatory ingredients without steroid to help moisturize and calm skin from inflammation. The aims of this study were to evaluate the efficacy and safety of MAS062D moisturizer lotion versus hydrophilic cream in improving the skin hydration and skin barrier function in the treatment of xerosis in the elderly. A split site, double-blinded, randomized, controlled trial was conducted in patients with mild to moderate xerosis. The patients applied MAS062D and hydrophilic cream on the assigned shins twice daily for 28days. The evaluations on each consecutive following up days (day 0, 14 and 28) were performed using clinical assessment, photography, measuring skin hydration by corneometer, transepidermal water loss (TEWL) by Tewameter and biometric assessment. Twenty four patients were included into the study of which 87.5% were female with mean age of 58.04 years and mean xerosis severity scale (XSS) of 4.83. MAI treated side have got the same statistically significant improvement in clinical assessment by XSS with the values of hydrophilic treated side presented at 4.83 ± 0.7, 3.33 ± 0.82 and 1.83 ± 0.82 on baseline, day 14 and 28 respectively. On the following up day 14 and 28, it indicated the statistically significant decrease in TEWL values measured by tewameter of the MAI treated side (5.4 ± 3.18g/m2h) (4.83 ± 1.84 g/m2h) compared to the hydrophilic cream treated side (8.63 ± 3.92g/m2h) (8.54 ± 4.53 g/m2h) (p |
