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IN VITRO CYTOTOXICITY OF CORDYCEPS MILITARIS EXTRACTS ON DIFFERENT HUMAN CANCER CELL LINES |
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| รหัสดีโอไอ | |
| Title | IN VITRO CYTOTOXICITY OF CORDYCEPS MILITARIS EXTRACTS ON DIFFERENT HUMAN CANCER CELL LINES |
| Creator | BUTKHUP LUCHAI |
| Contributor | KULLAWAT JITSUDA, CHOTTANOM PHEERAYA |
| Publisher | Faculty of Technology, Mahasarakham University |
| Publication Year | 2563 |
| Keyword | Codyceps militaris, Cordycepin, Adenosine, Cytotoxicity |
| Abstract | This study was conducted to evaluate the in vitro cytotoxicity of C. militaris extracts against cancer cells. The cytotoxic activity was tested using Resazurin reduction microplate assay (REMA). The in vitro assay for the C. militaris extracts was measured using three human cancer cells: Human hepatocellular carcinoma (HepG2), Human breast adenocarcinoma (MCF-7), and Cervical adenocarcinoma (HeLa). The REMA assay indicated that Ethyl alcohol (EtOH) and Ethyl acetate (EtOAc) extract of C. militaris exhibited significant cytotoxicity on MCF-7, HepG-2 and HeLa cancer cells in the dose-dependent manner. C. militaris extracted with EtOAc exhibited stronger cytotoxicity on MCF-7 than HepG2 and HeLa. The results obtained indicated that the probable use of the C. militaris extract in preparing recipes for cancer-related ailments. Further studies will identify bioactive compounds and elucidate more detailed molecular mechanisms of cell death. |
| Language | EN |
| URL Website | https://techno2.msu.ac.th/icofab/welcome/ |
| Website title | The 7th International Conference on Food Agriculture & Biotechnology(ICoFAB 2020) |
