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PRO-INFLAMMATION CYTOKINE SECRETION OF PERIPHERAL BLOOD MONONUCLEAR CELLS BY EDIBLE MUSHROOM |
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| รหัสดีโอไอ | |
| Title | PRO-INFLAMMATION CYTOKINE SECRETION OF PERIPHERAL BLOOD MONONUCLEAR CELLS BY EDIBLE MUSHROOM |
| Creator | SINEE SIRICOON |
| Contributor | PATTRA AHMADI PIRSHAHIDCHIRAMET AURANWIWAT, WIRIYAPORN SUMSAKUL, WARAPORN SORNDECH, THONGKORN PLOYPETCHARA, KWANCHAI RATTANAMANEE |
| Publisher | Faculty of Technology, Mahasarakham University |
| Publication Year | 2563 |
| Keyword | Cytokine, Anti-inflammatory activity, ELISA, Mushroom |
| Abstract | Inflammation is a natural process of the innate immune system that associated with the increase in the level of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-?), interleukin 1? (IL-1?) and interleukin 6 (IL-6). Prolonged inflammation, known as chronic inflammation, related to many chronic diseases such as autoimmune diseases, wound healing, rheumatoid arthritis and cardiovascular disease. The present study aims to investigate the effect of mushroom extracts on the cytokines secretion from lipopolysaccharide (LPS) stimulated peripheral blood mononuclear cells (PBMCs) involved in immune regulation. The secretion of TNF-?, IL-1? and IL-6 was measured by ELISA. The ethanol extract of all mushroom significantly reduced the production of TNF- ?. Furthermore, Lentinula edodes, Isaria tennipes, Pleurotus osttreatus and Lentinus squarrosulas Mont. were decreased IL-1? level and Pleurotus osttreatus, Isaria tennipes and Lentinus squarrosulas Mont. were significantly suppressed IL-6 secretion in LPS-treated PBMCs. The application of these extracts showed important anti-inflammatory activity which involved in the treatment and prevention of inflammation and associated diseases. |
| Language | EN |
| URL Website | https://techno2.msu.ac.th/icofab/welcome/ |
| Website title | The 7th International Conference on Food Agriculture & Biotechnology(ICoFAB 2020) |
