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Pancreatic Lipase Inhibitory Activity of Selected Herbal Infusions |
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| รหัสดีโอไอ | |
| Title | Pancreatic Lipase Inhibitory Activity of Selected Herbal Infusions |
| Creator | Nuanla-ong Kaeothaisong |
| Contributor | Mahasarakham University |
| Publisher | Mahasarakham University |
| Publication Year | 2559 |
| Keyword | Pancreatic lipase, anti-obesity, plant extract, herbal product |
| Abstract | Obesity is now an important public health issue throughout the world. Many methods have attempted to resolve this problem including specific pharmaceutical or herbal medicines as well as exercise regimes. Orlistat is one drug designed to treat obesity. It prevents the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. However, orlistat has some side effects. Thus, the use of plant extracts as treatment programs is more suitable than synthetic drugs. This study screened the potential anti-obesity effects of plant extracts and their ability to inhibit the pancreatic lipase enzyme. Pancreatic lipase inhibitory activity was tested with five Thai medicinal plants namely Bauhinia strychnifolia Craib, Cassia fistula L., Morus alba L., Moringa oleifera Lam, and Nelumbo nucifera Gaertn. The effect of herbal infusions on lipase inhibitory activity in vitro was examined by the colorimetric method, using p-nitrophenyl dodecanoate as a substrate. C. fistula leaf extract exhibited the best activity against pancreatic lipase enzyme with an IC50 of 38.372?1.509 ?g/mL. Orlistat was used as the positive control for pancreatic lipase inhibition. C. fistula leaf extract showed high inhibitory activity toward pancreatic lipase (0.353?0.055 mmol Orlistat/g dry weight). The results provide a basis for further investigations to identity active compounds from potential herb species. Further research is necessary for future development of effective and economical herbal anti-obesity products. |
