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ALPHA-GLUCOSIDASE INHIBITORS FROM DENDROBIUM TORTILE |
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| รหัสดีโอไอ | |
| Title | ALPHA-GLUCOSIDASE INHIBITORS FROM DENDROBIUM TORTILE |
| Creator | Rachawadee Limpanit |
| Contributor | Boonchoo Sritularak, Kittisak Likhitwitayawuid |
| Publisher | Chulalongkorn University |
| Publication Year | 2558 |
| Keyword | Glucosidase inhibitors, Dendrobium, สารยับยั้งเอนไซม์กลูโคซิเดส, หวาย (กล้วยไม้) |
| Abstract | Phytochemical investigation of the crude methanol extract of Dendrobium tortile (Orchidaceae) led to the isolation of a new compound, namely 4-(2-hydroxypropyl)-2(5H)-furanone, together with six known compounds,which included trans-tetracosylferulate, cis-hexacosanoyl ferulate, p-hydroxybenzaldehyde, 3,4-dihydroxy-5,4'-dimethoxybibenzyl, eriodictyol and dendrofalconerol A. The structures of these compounds were determined through analysis of 1-D and 2-D NMR and HR-ESI-MS data. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Dendrofalconerol A showed strong activity when compared with the positive control acarbose, whereas 3,4-dihydroxy-5,4'-dimethoxybibenzyl and eriodictyol showed appreciable effects. An enzyme kinetics study revealed that dendrofalconerol A is a reversible non-competitive inhibitor of α-glucosidase. This is the first report on the chemical composition and the biological activity of D. tortile. |
| URL Website | cuir.car.chula.ac.th |
