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BIOACTIVE COMPOUNDS FROM STEM BARK OF Derris indica (Lamk.) Bennet |
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| รหัสดีโอไอ | |
| Title | BIOACTIVE COMPOUNDS FROM STEM BARK OF Derris indica (Lamk.) Bennet |
| Creator | Pornpat Anusiri |
| Contributor | Khanitha Pudhom, Nattaya Ngamrojanavanich |
| Publisher | Chulalongkorn University |
| Publication Year | 2556 |
| Keyword | Plant extracts, Chromatographic analysis, Biotechnology, สารสกัดจากพืช, โครมาโตกราฟี, เทคโนโลยีชีวภาพ |
| Abstract | The present study focuses on isolation and characterization of bioactive compounds from stem bark of Derris indica (Lamk.) Bennet. The ethyl acetate crude extract was purified by chromatographic techniques. Chemical examination of D. indica resulted in isolation and characterization of two new flavonoids, derrisins A (5) and B (9), together with 11 known compounds including desmethoxy kanugin (1), pongaglabrone (2), pongachromene (3), pongapin (4), karanjin (6), 3,7,4'–trimethoxyflavone (7), fisetin tetramethyl ether (8), pinnatin (10), lacneolatin B (11), pongaflavone (12), and 5-methoxy-3',4'-methylenedioxy(8,7-4'',5'')flavone (13). Their chemical structures were determined on the basis of spectroscopic data analysis and by comparison with those in the literature. All compounds were tested for anti-inflammatory and antiglycation activities. Pongaflavone (12) and desmethoxy kanugin (1) displayed anti-inflammatory activity by suppressing nitric oxide production with the IC50 values of 14.59 and 22.83 µM, respectively, while derrisin B (9) exhibited the most potent inhibitory activity against the formation of advanced glycation end products (AGEs) by trapping reactive methylglyoxal with the IC50 value of 18.00 µM. |
| URL Website | cuir.car.chula.ac.th |
