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One-pot synthesis of aryl ketone from carboxylic acid via friedel-craft acylation |
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| รหัสดีโอไอ | |
| Title | One-pot synthesis of aryl ketone from carboxylic acid via friedel-craft acylation |
| Creator | Atthapol Kasemsuknimit |
| Contributor | Warinthorn Chavasiri |
| Publisher | Chulalongkorn University |
| Publication Year | 2551 |
| Keyword | Friedel-Crafts reaction, Carboxylic acid, Acylation |
| Abstract | The mild and efficient approach for aryl ketones synthesis from carboxylic acids has been developed. Aryl ketones can be synthesized by Friedel-Crafts acylation of aromatic compounds with acid halides in situ generated from halogenating agent and PPh3. The optimal conditions for the synthesis of 4-methoxybenzophenone as a model reaction are thoroughly scrutinized. The reaction is composed of two steps: the first step is the conversion of benzoic acid to benzoyl chloride by combination of Cl3CCN and PPh3, while the second step is Friedel-Craft acylation between anisole and the in situ generated acylating agent in the presence of AlCl3. This developed one-pot protocol which has never been reported in chemical literatures can be efficiently performed under mild conditions with short reaction time furnishing good to excellent yields of the desired aryl ketone, particularly for activated aromatic compounds. |
| URL Website | cuir.car.chula.ac.th |
