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Enhanced dissolution of silymarin by solid dispersion technique and inhibitory effect of silymarin against cisplatin-induced nephrotoxicity |
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| รหัสดีโอไอ | |
| Title | Enhanced dissolution of silymarin by solid dispersion technique and inhibitory effect of silymarin against cisplatin-induced nephrotoxicity |
| Creator | Pacharaporn Jiamchaisri |
| Contributor | Angkana Tantituvanont, Pithi Chanvorachote, Kulwara Meksawan |
| Publisher | Chulalongkorn University |
| Publication Year | 2551 |
| Keyword | Silymarin -- การละลาย, Nephrotoxicology, Cisplatin, ซิไลมาริน -- การละลาย, ความเป็นพิษต่อไต, ซิสพลาติน |
| Abstract | Silymarin has beneficial effects in the prevention and the treatment of liver disease, however, the bioavailability of silymarin is limited by its poor solubility in water. The preparation of silymarin by solid dispersion technique may improve the dissolution of silymarin. The enhancement of dissolution is caused by an interaction between drugs and hydrophilic carriers. The dissolution characteristics of the drug depend on the type and ratio of carrier used. For this reason, one of the objectives of this study was to investigate the effect of polyethylene glycol 4000, 6000 and polyvinylpyrrolidone K 30 at the ratio silymarin to carrier for 1 : 2, 1 : 4 and 1 : 8 on the dissolution of silymarin prepared by solid dispersion technique using fluidized-bed coating technique. The results suggested that percent dissolved of silymarin solid dispersion pellets were higher than silymarin powder. Silymarin solid dispersion pellets using polyethylene glycol 6000 at all ratios provided the higher percent dissolved of silymarin than polyethylene glycol 4000 and polyvinylpyrrolidone K 30 at the same ratio. In addition for the treatment of liver disease, silymarin was found to be synergist with cisplatin in the treatment of cancers. Cisplatin caused cytotoxicity in normal cells especially kidney cells. Silymarin reduced the cisplatin-induced cytotoxicity in normal cells but this protective effect is unclear. For this reason, another objective in this study was to investigate the inhibitory effect of silymarin against cisplatin-induced cytotoxicity in human kidney cells (HK-2 cells). The results suggested that silymarin showed protective effect against cisplatin-induced cytotoxicity in HK-2 cells by decreasing the number of cell death. The protective effect of silymarin may be due to its ability to scavenge hydrogen peroxide and hydroxyl radical. Cisplatin-induced cytotoxicity is caused by the production of these radicals. |
| URL Website | cuir.car.chula.ac.th |
