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Chitosan nanoparticle as all-trans-retinyl acetate carrier : characterization and controlled release |
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| รหัสดีโอไอ | |
| Title | Chitosan nanoparticle as all-trans-retinyl acetate carrier : characterization and controlled release |
| Creator | Mayura Wittayasuporn |
| Contributor | Supasorn Wanichvecharungruang, Sirirat Rengpipat |
| Publisher | Chulalongkorn University |
| Publication Year | 2550 |
| Keyword | Chitosan, Nanoparticle |
| Abstract | In this work, mPEG-phthaloylchitosan (PPLC) and mPEG-4-methoxycinnamoylphthaloylchitosan (PCPLC) were synthesized. The PPLC and PCPLC were induced into nanoparticle by solvent displacement method. Their size and zeta potential were in the range of 50-60 nm and -23-30 mV, respectively. The antibacterial activity of mPEG-phthaloylchitosan (PPLC) and mPEG-4-methoxycinnamoylphthaloylchitosan (PCPLC) nanoparticles was evaluated by a turbidity method. Result showed that both nanoparticles could inhibit the growth of the Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. Cytotoxicity evaluation of both nanoparticles indicated that both nanoparticles were not harmful toe human melanoma skin cell lines. In addition, All-trans retinyl acetate (ATRA) was loaded into both nanoparticles. Study of the pH effect (pH 4, 7 and 10) on release behaviors of ATRA from particles was investigated by dialysis method. The results indicated that the ATRA release was maximum at neutral pH. |
| URL Website | cuir.car.chula.ac.th |
