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INVESTIGATING THE INFLUENCE OF ACTN3 R577X POLYMORPHISM ON ANGULAR KINEMATICS USING MOTION CAPTURE TECHNOLOGY |
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| รหัสดีโอไอ | |
| Creator | Pongpanot Wongveerakul |
| Title | INVESTIGATING THE INFLUENCE OF ACTN3 R577X POLYMORPHISM ON ANGULAR KINEMATICS USING MOTION CAPTURE TECHNOLOGY |
| Contributor | Thet Hnin Moe, Vitoon Saengsirisuwan, Nongnapas Charoenpanich, Ioannis Papadimitriou1 |
| Publisher | Thailand National Sports University |
| Publication Year | 2565 |
| Journal Title | Academic Journal of Thailand National Sports University |
| Journal Vol. | 14 |
| Journal No. | 1 |
| Page no. | 9-20 |
| Keyword | Genetics, Biomechanics, Performance, Jumps, Velocity, Acceleration |
| URL Website | https://he02.tci-thaijo.org/index.php/TNSUJournal/index |
| Website title | เว็บไซต์วารสารวิชาการมหาวิทยาลัยการกีฬาแห่งชาติ |
| ISSN | Print 2673-0952 Online 2697-5793 |
| Abstract | ACTN3 has been labeled as the ‘gene for speed’ due to the increased frequency of the R allele encoding the α – actinin - 3 protein in elite sprint athletes compared to the general population. In situ muscle fibers that express α – actinin - 3 protein can produce more force than the muscle fibers that are α – actinin - 3 deficient (ACTN3 XX genotype). In vivo, using single joint isokinetic dynamometry assessments individuals with ACTN3 RR genotype demonstrated higher peak torque at all angular speeds (30 - 180o/s) than those with ACTN3 XX genotype. However, no study so far has investigated the influence of the ACTN3 gene on angular velocity and acceleration during vertical jumps using motion capture technology. The aim of this study was to investigate the influence of the ACTN3 gene on Squat Jump (SJ), by comparing maximal angular velocity and acceleration in hip and knee joint between ACTN3 RR and ACTN3 XX homozygotes. The biomechanical data were obtained using Qualisys Track Manager (QTM) motion analysis system and the DNA was isolated from white blood cells. The 291 - bp PCR fragment was electrophoresed, visualized in UV light and finally digested with Hpy8 restriction endonuclease. No statistically significant differences were observed; However, ACTN3 RR homozygotes demonstrated a trend towards higher maximal angular velocity and acceleration at take-off during SJ jumps (RR 4533.61 ± 1067.62 deg/s2 vs. XX 3183.53 ± 1695.99 deg/s2) in hip joint compared to their ACTN3 XX counterparts. This study suggests that more participants are required to investigate the potential underlying ACTN3 gene effect on angular kinematics during explosive movements such as vertical jumps. |
