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Formulation and physicochemical properties of resveratrol-loadedlipid-nanocarriers |
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| รหัสดีโอไอ | |
| Creator | 1. Benchawan Chamsai 2. Praneet Opanasopit 3. Pornsak Sriamornsak 4. Chitralada Vasarach 5. Wipada Samprasit |
| Title | Formulation and physicochemical properties of resveratrol-loadedlipid-nanocarriers |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2022 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 2 |
| Page no. | 488-495 |
| Keyword | resveratrol, lipid-nanocarriers, gels, nanostructured lipid carriers, nanoemulsions |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | The study aimed to prepare and evaluate the physicochemical properties of resveratrol (Res)-loaded lipid-nanocarriersincluding nanostructured lipid carriers (NLCs) and nanoemulsions (NEs). The effects of composition and process parameters onthe physicochemical properties were demonstrated. The optimal formulation was selected to prepare the nanocarrier gels. Thepossible use of the lipid-nanocarriers in gels and their physical appearances was observed by visual inspection. The resultsshowed that small carriers were prepared by homogenization at 6000 rpm for 5 min. The emulsifier system of Tweenยฎ80,Spanยฎ80 and diethylene glycol monoethyl ether (DGME) provided good physical stability. The NEs could be prepared for Resloaded NE gels (NEGs) with minimum particle size and optimal zeta potential. Alkyl acrylate crosspolymer (PPM) was the bestgelling agent in the formulation. Moreover, the blend of NE and gels (NEGs) was easy to spread on the skin with good occlusiveproperty. Thus, these NEGs have a potential to a nanocarrier for topical delivery of Res |
