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Assessment of DNA damage in the heroin addicted population ofKhyber Pakhtunkhwa, Pakistan using alkaline comet assay |
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| รหัสดีโอไอ | |
| Creator | 1. Muhammad Jawad 2. Muhammad Zahid 3. Faheem Ullah 4. Mudassir Shah 5. Abdul Wahab 6. Muhammad Ismail Khan |
| Title | Assessment of DNA damage in the heroin addicted population ofKhyber Pakhtunkhwa, Pakistan using alkaline comet assay |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2022 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 2 |
| Page no. | 348-352 |
| Keyword | heroin addicted population, DNA damage, comet assay, genotoxicity |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | The study was conducted to gain knowledge about the assessment of DNA damage in the population of heroin addictsand also to learn about the related health complications in drug abusers. A total of 103 samples of blood were collected from 65heroin addicted subjects and 38 control subjects. For evaluation of DNA damage in the heroin addicted group, a comet assaytechnique was carried out. The results demonstrated that significant DNA damage 167.35ยฑ16.49 (P<0.05) was found in subjectswho were addicted to heroin as compared to the control group having cells without any DNA damage 53.02ยฑ25.03. Thepopulation which were positive for human immunodeficiency virus infection had the highest total comet score values followedby asthma and hepatitis C virus. The total comet score increased significantly with age group. Significantly, the highestgenotoxicity was concluded in the heroin addicted population. |
