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Can polydatin have a beneficial role against bisphenolan exposure in rats? |
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| รหัสดีโอไอ | |
| Creator | 1. Recep Aslan 2. Hasan Hรผseyin Demirel 3. Fatih Avdatek 4. Aziz Bรผlbรผl 5. Abdullah Eryavuz 6. Mehmet ลรผkrรผ Gulay |
| Title | Can polydatin have a beneficial role against bisphenolan exposure in rats? |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2022 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 1 |
| Page no. | 223-230 |
| Keyword | BPA toxicity, oxidative stress, polydatin, spermatological parameters |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | The present study was conducted to evaluate the effects of chronic bisphenol A (BPA) exposure and the possibleprotective effects of polydatin (PD) on different organs, oxidant-antioxidant status and spermatological parameters in maleWistar rats. Male Wistar rats (2 to 3 months old) were randomly divided into 5 groups (n = 6). Group 1 was the control (daily0.5ml distilled water). Groups 2, 3, 4 and 5 daily received 0.5 ml olive oil (OO), 25 mg/kg bisphenol A in 0.5 olive oil (BPA),150 mg/kg polydatin (PD), and a mixture of 25 mg/kg bisphenol A in 0.5 olive oil + 150 mg/kg polydatin (BPA-PD),respectively, daily for 45 days. BPA had negative effects on percent abnormal sperm and Hypo-osmotic swelling-Eosin (HE) test(P<0.01). BPA caused negative histopathological alterations to the brain, heart, liver, kidney, and testis tissues. PDadministration was able to ameliorate the negative effects of BPA. Moreover, PD had positive effects on percent motility(P<0.02), head defects of sperm (P<0.01), and HE test (P<0.01) when compared to the controls. The results indicate that PDdecreases BPA-induced sperm defects and repaired tissue damage in the various organs in rats. |
