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Antibacterial efficiency enhancement of gentamicin sulfate encapsulatedCuS nanoparticles |
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| รหัสดีโอไอ | |
| Creator | 1. Padikkamannil Abishad 2. Namratha Keerthiraj 3. Srinath B. S. 4. Jayashankar Madayya 5. Jess Vergis 6. Byrappa Kullaiya |
| Title | Antibacterial efficiency enhancement of gentamicin sulfate encapsulatedCuS nanoparticles |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2022 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 5 |
| Page no. | 1345-1352 |
| Keyword | gentamicin sulfate, CuS nanoparticles, myconanotechnology, biosynthesis, cytotoxicity |
| URL Website | https://sjst.psu.ac.th/ |
| ISSN | 0125-3395 |
| Abstract | The use of engineered semiconductor nanomaterials to address multi-drug resistance in bacteria has gained attention. Inthis study, an environmentally friendly cost-effective biological approach to synthesize copper sulfide nanoparticles (CuS-NPs) isreported. The CuS-NPs and the antibiotic Gentamicin Sulfate (GS) at the concentration of 40 ?g/mL exhibit significantsynergistic inhibition against several human pathogens (E. coli, Salmonella typhi, Klebsiella pneumoniae, Staphylococcusaureus, and Bacillus subtilis). The effective release of antibiotic and less frequent administration are therapeutic advantages. Thedrug entrapment and loading capacity of synthesized CuS nanoparticles (CuS-NP) were recorded as 61% and 39%, respectively.Additionally, a promising activity of the mycosynthesized CuS-NP is an increased cytotoxicity against MDA-MB-231 breastcancer cell line, as indicated by the estimated IC50 value. |
