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Characterization, metal chelation and anti-cancerous activity ofextracelluar melanin pigments produced byPseudomonas mosselii STSGRDS1 |
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| รหัสดีโอไอ | |
| Creator | 1. Trisha Mary P. A. 2. Sharmila Srimathi D. 3. Arya R. Krishna, Jayaprabha. C 4. Swathy Krishna J. 5. Suganthi Ramasamy |
| Title | Characterization, metal chelation and anti-cancerous activity ofextracelluar melanin pigments produced byPseudomonas mosselii STSGRDS1 |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2021 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 43 |
| Journal No. | 4 |
| Page no. | 1041-1048 |
| Keyword | melanin, Pseudomonas mosselii, anti-cancer, metal chelation, MIC |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Melanins are ubiquitous pigments which are naturally produced and distributed throughout the biological kingdom.Pseudomonas mosselii strain STSGRDS1 producing melanin was used in the study. STSGRDS1 melanin reported to have metalchelating potential of increasing effect with increase in the concentration of melanin. The anti-proliferative activity of thepurified melanin by MTT assay had IC50 value 87.15?g/ml towards A431skin cancer cell line for standard 5-flurouracil and alsoshowed substantial apoptotic activity. The minimal inhibitory concentration (MIC) against bacteria and fungi were alsoevaluated. Hence, the purified melanin having anti-proliferative properties can be exploited in therapeutic applications. |
