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Anti-inflammatory effect of Moringa oleifera Lam. leaf extract onUVB-irradiated human keratinocytes |
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| รหัสดีโอไอ | |
| Creator | 1. Jinutda Engsuwan 2. Neti Waranuch 3. Nanteetip Limpeanchob 4. Kornkanok Ingkaninan |
| Title | Anti-inflammatory effect of Moringa oleifera Lam. leaf extract onUVB-irradiated human keratinocytes |
| Publisher | Research and Development Office,Prince of Songkla University |
| Publication Year | 2021 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 43 |
| Journal No. | 3 |
| Page no. | 774-780 |
| Keyword | Moringa oleifera, astragalin, anti-inflammatory activity, primary human skin cells, UVB |
| URL Website | https://rdo.psu.ac.th/sjstweb/ |
| ISSN | 0125-3395 |
| Abstract | Moringa oleifera Lam. has multiple biological properties that are applicable to developing cosmeceuticals. Theobjective of this study was to evaluate anti-inflammatory effects of M. oleifera on normal human keratinocytes. The antiinflammatory effects of water extract and 50% ethanol extract of M. oleifera leaves, and of the bioactive compound astragalin, onUVB-irradiated human keratinocytes were investigated. The levels of inflammatory mediators IL-1๏ก, IL-8, NO and PGE2released from keratinocytes were measured using ELISA and Griess assays. UVB irradiation increased the release of IL-1๏ก, IL-8and PGE2 into cell culture media after 24 h. The effect was significantly decreased by treatments with astragalin and M. oleiferaleaf extracts, of which the 50% ethanol extract showed stronger inhibition than the water extract. These results suggest that thisextract is a potential ingredient in products for relieving UVB-induced skin inflammation. Astragalin could be used as a bioactivepositive control in the quality control of the extract. |
