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Comparative effects of coconut water and N-Acetyl cysteine on the hypothalamo-pituitary-gonadal axis of male rats |
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| รหัสดีโอไอ | |
| Creator | 1. Olufadekemi Tolulope Kunle-Alabi 2. Opeyemi Oreofe Akindele 3. Maximillian I. Odoh 4. Bright Onome Oghenetega 5. Yinusa Raji |
| Title | Comparative effects of coconut water and N-Acetyl cysteine on the hypothalamo-pituitary-gonadal axis of male rats |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2017 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 39 |
| Journal No. | 6 |
| Page no. | 759 |
| Keyword | coconut water,cysteine,danazol,fertility |
| ISSN | 0125-3395 |
| Abstract | Coconut water (CW) contains cysteine, an amino acid which influences glutathione metabolism and promotesreproductive functions. The effects of CW and N-acetyl cysteine (NAC) were compared on the hypothalamo-pituitary-gonadal-axisof danazol-(a GnRH antagonist)-treated rats. Seven groups of male rats were treated orally for six weeks as follows;1: 20 mL/kg distilled water (Control); 2: 20 mL/kg Corn oil; 3: 20 mL/kg CW; 4: 100 mg/kg NAC; 5: 200 mg/kg Danazol;6: Danazol+CW; 7: Danazol+NAC. Serum gonadotropins and testosterone; sperm indices; testicular malondialdehyde andglutathione were determined. Sperm quality increased in groups 3, 4, 6 and 7, and reduced in group 5 compared with groups1 and 2. Gonadotropins and testosterone increased in groups 6 and 7 compared with group 5. Malondialdehyde reduced,while glutathione increased, in groups 3 and 4 compared with group 1. These similarities suggest that cysteine contributes tothe effects of coconut water along the hypothalamo-pituitary-gonadal-axis. |
