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Wound healing activity of Curcuma zedoaroides |
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| รหัสดีโอไอ | |
| Creator | 1. Pattreeya Tungcharoen 2. Teeratad Sudsai 3. Sukanlaya Leejae 4. Chatchai Wattanapiromsakul 5. Pimpimon Tansakul 6. Supinya Tewtrakul |
| Title | Wound healing activity of Curcuma zedoaroides |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2016 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 38 |
| Journal No. | 6 |
| Page no. | 621-630 |
| Keyword | Curcuma zedoaroides,anti-inflammation,wound healing effect |
| ISSN | 0125-3395 |
| Abstract | Curcuma zedoaroides rhizomes have been used in Thai folk medicine as antidote and wound care for king cobra bitewound. The inhibitory effect of C. zedoaroides extract and its fractions on inflammation were detected by reduction of nitricoxide release using RAW264.7 cells. The improvement capabilities on wound healing were determined on fibroblast L929cells proliferation and migration assays. The results showed that crude EtOH extract, CHCl3 and hexane fractions inhibitedNO release with IC50 values of 14.0, 12.4 and 14.6 ?g/ml, respectively. The CHCl3 and EtOAc fractions significantly increasedL929 cells proliferation, enhanced fibroblast cells migration (100%) on day 3 and scavenged DPPH with IC50 of 40.9 and 7.2?g/ml, respectively. Only the CHCl3 fraction showed marked effect against carrageenan-induced rat paw edema (IC50 = 272.4mg/kg). From the present study, both in vitro and in vivo models support the traditional use of C. zedoaroides. |
