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Development of curcumin liposome formulations using polyol dilution method |
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| รหัสดีโอไอ | |
| Creator | 1. Lalana Kongkaneramit 2. Porntipa Aiemsum-ang 3. Prartana Kewsuwan |
| Title | Development of curcumin liposome formulations using polyol dilution method |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2016 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 38 |
| Journal No. | 6 |
| Page no. | 605-610 |
| Keyword | liposomes,polyol,curcumin,entrapment,TEM |
| ISSN | 0125-3395 |
| Abstract | This study was aimed to formulate curcumin liposomes (CLs) by using polyol dilution method which is advantageousfor no residue of organic solvent. CLs were the mixture of hydrogenated phosphatidylcholine (PC) and cholesterol (CH) atthe molar ratio of 9:1. Propylene glycol (PG), glycerin, and polyethylene glycol 400 (PEG-400) were used as polyol solvent.Extrusion was applied after the suspension formed. The amount of polyol and curcumin and preparing temperature wereinvestigated. The obtained suspensions were observed for appearance, size, size distribution, zeta potential, morphology,and percentage of entrapment. The results showed that type and amount of polyol had an impact on both liposomal size andthe amount of entrapped curcumin, while preparing temperature was also an important factor. However, the solubility of lipidsand drug in a given polyol should be considered because of loading efficiency in the formulation |
