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Fresh garlic extract inhibits Staphylococcus aureus biofilm formationunder chemopreventive and chemotherapeutic conditions |
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| รหัสดีโอไอ | |
| Creator | 1. Panan Ratthawongjirakul 2. Vorraruthai Thongkerd |
| Title | Fresh garlic extract inhibits Staphylococcus aureus biofilm formationunder chemopreventive and chemotherapeutic conditions |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2016 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 38 |
| Journal No. | 4 |
| Page no. | 381-389 |
| Keyword | fresh garlic extract,biofilms,MRSA,Staphylococcus aureus |
| ISSN | 0125-3395 |
| Abstract | Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) are the leading aetiologicalpathogens of nosocomial infections worldwide. These bacteria form biofilms on both biotic and abiotic surfaces causingbiofilm-associated infections. Within the biofilm, these bacteria might develop persistent and antimicrobial resistant characteristicsresulting in chronic infections and treatment failures. Garlic exhibits broad pharmaceutical properties and inhibitoryactivities against S. aureus. We investigated the effects of aqueous fresh garlic extract on biofilm formation in S. aureusATCC25923 and MRSA strains under chemopreventive and chemotherapeutic conditions. The viable bacteria and biofilmlevels were quantified through colony count and crystal violet staining, respectively. The use of fresh garlic extract underboth conditions significantly inhibited biofilm formation in S. aureus strains ATCC25923 and MRSA. Garlic could bedeveloped as either a prophylactic or therapeutic agent to manage S. aureus biofilm-associated infections. |
