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Changes of androgen receptor expression in stages VII-VIII seminiferoustubules of rat testis after exposure to methamphetamine |
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| รหัสดีโอไอ | |
| Creator | 1. Sutita Nudmamud-Thanoi 2. Nareelak Tangsrisakda 3. Samur Thanoi |
| Title | Changes of androgen receptor expression in stages VII-VIII seminiferoustubules of rat testis after exposure to methamphetamine |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2016 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 38 |
| Journal No. | 3 |
| Page no. | 275-279 |
| Keyword | methamphetamine,seminiferous tubule,androgen receptor,spermatogenesis,testis |
| ISSN | 0125-3401 |
| Abstract | Methamphetamine (METH) is toxic not only to the central nervous system but also to the reproductive system. Thisstudy aimed to investigate the effect of METH administration on androgen receptor (AR) expression in the seminiferoustubules (stages VII-VIII) and Leydig cells. 24 Sprague-Dawley rats were equally divided into 4 groups; control, acute doseMETHbinge (AB-METH), escalating dose-METH (ED-METH) and escalating dose-METH binge (ED-METH binge) groups.The expressions of AR were examined using immunohistochemical staining. AR expressions in round and elongatedspermatids showed significant decreases in ED-METH binge and AB-METH groups. In Leydig's cells, AR expressions weresignificantly decreased in both ED-METH and ED-METH binge groups. These results could reflect the effect of METH onthe expressions of AR in both round and elongated spermatids of stages VII-VIII seminiferous tubule and Leydig's cells.Decreases of AR expressions in those cells of METH-treated animals may interrupt spermatogenesis at these stages. |
