รหัสดีโอไอ 10.14456/amjam.2021.46
Creator Nattapon Wongcumchang
Title Efficacy of A Mydriatic Mixture of 0.5% Tropicamide and 5% Phenylephrine at Thammasat University Hospital
Contributor Tarawadee Chawarung
Publisher Thammasat Printing House
Publication Year 2021
Journal Title Asian Medical Journal and Alternative Medicine
Journal Vol. 21
Journal No. 1
Page no. 7
Keyword Mydriatics, Phenylephrine, Tropicamide, Pupillary dilatation
URL Website http://asianmedjam.com/
Website title asianmedjam
ISSN 2730-3578
Abstract Purpose: To compare the effectiveness of mydriasis between mydriatic mixtures of 0.5% tropicamide and 5% phenylephrine versus 1% tropicamide and 10% phenylephrine.Design: Prospective randomized controlled trialMethods: In this study, 30 Asian patients with dark irides were randomized to receive topical 1% tropicamide and 10% phenylephrine (conventional regimen), and 30 patients to receive a fixed combination of 0.5% tropicamide and 5% phenylephrine (mixed regimen). The vertical pupillary dilatation, blood pressure, and pulses were studied. Results:Sixty patients were equally randomized into conventional and mixed regimens. For the conventional and mixed regimen groups; the mean baseline pupil diameter was 1.49 ? 0.62 mm and 1.84 ? 0.64 mm, respectively. The mean pupil diameter at 15 minutes was statistically significant difference between both groups, 3.79 ? 0.90 mm in the conventional regimen group and 4.30 ? 1.05 mm in the mixed regimen group with mean difference 0.5133 mm (95%CI 0.0076 - 1.0191, P = 0.047). Whereas the mean pupil diameter at 30, 45, and 60 minutes showed no significant difference between groups. In the first 30 minutes, the proportion of eyes that achieved 7 mm pupil size between both groups was significant difference, 36.7% in the conventional regimen group, and 63.3% mixed regimen group (P = 0.039). At 60 minutes, the proportion was 86.7% and 96.7% respectively (P = 0.353). There was no significant difference in arterial blood pressure and pulse rate between groups. Conclusion: The mixture of 0.5% tropicamide and 5% phenylephrine showed comparable efficacy to a conventional regimen and resulted in greater pupillary dilatation within the first 15 minutes, allowing for more rapid achievement of desired mydriasis.
ดิจิตอลไฟล์ Digital File

บรรณานุกรม

Nattapon Wongcumchang และ Tarawadee Chawarung. (2021) Efficacy of A Mydriatic Mixture of 0.5% Tropicamide and 5% Phenylephrine at Thammasat University Hospital. Asian Medical Journal and Alternative Medicine, 21(1), 7.
Nattapon Wongcumchang และ Tarawadee Chawarung. "Efficacy of A Mydriatic Mixture of 0.5% Tropicamide and 5% Phenylephrine at Thammasat University Hospital". Asian Medical Journal and Alternative Medicine 21 (2021):7.
Nattapon Wongcumchang และ Tarawadee Chawarung. Efficacy of A Mydriatic Mixture of 0.5% Tropicamide and 5% Phenylephrine at Thammasat University Hospital. Thammasat Printing House:ม.ป.ท. 2021.