Efficacy of A Mydriatic Mixture of 0.5% Tropicamide and 5% Phenylephrine at Thammasat University Hospital
รหัสดีโอไอ
Creator Nattapon Wongcumchang
Title Efficacy of A Mydriatic Mixture of 0.5% Tropicamide and 5% Phenylephrine at Thammasat University Hospital
Contributor Tarawadee Chawarung
Publisher Thammasat Printing House
Publication Year 2564
Journal Title Asian Medical Journal and Alternative Medicine
Journal Vol. 21
Journal No. 1
Page no. 7
Keyword Mydriatics, Phenylephrine, Tropicamide, Pupillary dilatation
URL Website http://asianmedjam.com/
Website title asianmedjam
ISSN 2730-3578
Abstract Purpose: To compare the effectiveness of mydriasis between mydriatic mixtures of 0.5% tropicamide and 5% phenylephrine versus 1% tropicamide and 10% phenylephrine.Design: Prospective randomized controlled trialMethods: In this study, 30 Asian patients with dark irides were randomized to receive topical 1% tropicamide and 10% phenylephrine (conventional regimen), and 30 patients to receive a fixed combination of 0.5% tropicamide and 5% phenylephrine (mixed regimen). The vertical pupillary dilatation, blood pressure, and pulses were studied. Results:Sixty patients were equally randomized into conventional and mixed regimens. For the conventional and mixed regimen groups; the mean baseline pupil diameter was 1.49 ? 0.62 mm and 1.84 ? 0.64 mm, respectively. The mean pupil diameter at 15 minutes was statistically significant difference between both groups, 3.79 ? 0.90 mm in the conventional regimen group and 4.30 ? 1.05 mm in the mixed regimen group with mean difference 0.5133 mm (95%CI 0.0076 - 1.0191, P = 0.047). Whereas the mean pupil diameter at 30, 45, and 60 minutes showed no significant difference between groups. In the first 30 minutes, the proportion of eyes that achieved 7 mm pupil size between both groups was significant difference, 36.7% in the conventional regimen group, and 63.3% mixed regimen group (P = 0.039). At 60 minutes, the proportion was 86.7% and 96.7% respectively (P = 0.353). There was no significant difference in arterial blood pressure and pulse rate between groups. Conclusion: The mixture of 0.5% tropicamide and 5% phenylephrine showed comparable efficacy to a conventional regimen and resulted in greater pupillary dilatation within the first 15 minutes, allowing for more rapid achievement of desired mydriasis.
Faculty of Medicine, Thammasat University

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