| รหัสดีโอไอ | 10.14456/amjam.2021.46 |
|---|---|
| Creator | Nattapon Wongcumchang |
| Title | Efficacy of A Mydriatic Mixture of 0.5% Tropicamide and 5% Phenylephrine at Thammasat University Hospital |
| Contributor | Tarawadee Chawarung |
| Publisher | Thammasat Printing House |
| Publication Year | 2021 |
| Journal Title | Asian Medical Journal and Alternative Medicine |
| Journal Vol. | 21 |
| Journal No. | 1 |
| Page no. | 7 |
| Keyword | Mydriatics, Phenylephrine, Tropicamide, Pupillary dilatation |
| URL Website | http://asianmedjam.com/ |
| Website title | asianmedjam |
| ISSN | 2730-3578 |
| Abstract | Purpose: To compare the effectiveness of mydriasis between mydriatic mixtures of 0.5% tropicamide and 5% phenylephrine versus 1% tropicamide and 10% phenylephrine.Design: Prospective randomized controlled trialMethods: In this study, 30 Asian patients with dark irides were randomized to receive topical 1% tropicamide and 10% phenylephrine (conventional regimen), and 30 patients to receive a fixed combination of 0.5% tropicamide and 5% phenylephrine (mixed regimen). The vertical pupillary dilatation, blood pressure, and pulses were studied. Results:Sixty patients were equally randomized into conventional and mixed regimens. For the conventional and mixed regimen groups; the mean baseline pupil diameter was 1.49 ? 0.62 mm and 1.84 ? 0.64 mm, respectively. The mean pupil diameter at 15 minutes was statistically significant difference between both groups, 3.79 ? 0.90 mm in the conventional regimen group and 4.30 ? 1.05 mm in the mixed regimen group with mean difference 0.5133 mm (95%CI 0.0076 - 1.0191, P = 0.047). Whereas the mean pupil diameter at 30, 45, and 60 minutes showed no significant difference between groups. In the first 30 minutes, the proportion of eyes that achieved 7 mm pupil size between both groups was significant difference, 36.7% in the conventional regimen group, and 63.3% mixed regimen group (P = 0.039). At 60 minutes, the proportion was 86.7% and 96.7% respectively (P = 0.353). There was no significant difference in arterial blood pressure and pulse rate between groups. Conclusion: The mixture of 0.5% tropicamide and 5% phenylephrine showed comparable efficacy to a conventional regimen and resulted in greater pupillary dilatation within the first 15 minutes, allowing for more rapid achievement of desired mydriasis. |
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