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Clinical Characteristics and Outcomes of Acute Myeloid Leukemia in Vajira Hospital-a 9-year Single Center Retrospective Study |
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| รหัสดีโอไอ | |
| Creator | Dusit Jit-ueakul |
| Title | Clinical Characteristics and Outcomes of Acute Myeloid Leukemia in Vajira Hospital-a 9-year Single Center Retrospective Study |
| Publisher | Text and Journal Publication |
| Publication Year | 2565 |
| Journal Title | Vajira Medical Journal |
| Journal Vol. | 66 |
| Journal No. | 2 |
| Page no. | 85-94 |
| Keyword | acute myeloid leukemia, chemotherapy, performance status, survival |
| URL Website | https://tci-thaijo.org/index.php/VMED |
| Website title | Vajira Medical Journal (วชิรเวชสาร) |
| ISSN | 0125-1252 |
| Abstract | Objective: To collect demographic data, management patterns and outcomes of acute myeloid leukemia (AML) patients in a tertiary hospital. Methods: We collected data of newly diagnosed AML patients from 2008 to 2016, including clinical presentation and characteristics at the time of diagnosis. Survivals and factors affecting outcomes were evaluated. Results: There were 106 patients enrolled in the study. More than half of the patients were in the younger age group, which had a median age 56.5 years (41.5-73.5). Initial symptoms at presentation were anemia, fever and bleeding tendency. The younger age group had a good performance status presented by Eastern Cooperative Oncology Group (ECOG) score of less than two. Intensive chemotherapy was utilized in treatment of most patients in the younger group (85.7%) as compared with the elderly group (18%). Better intensive chemotherapy significantly improved median survival (256 vs 79 days; p < 0.001). Conclusion: AML patients who had received intensive chemotherapy had a survival advantage irrespective of age. |
