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Estrogen, Progesterone and Her-2 Receptors Status in Breast Cancer Patients |
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| รหัสดีโอไอ | |
| Creator | 1. Kanisa Rongsriyam 2. Marisa Chongthanakorn 3. Thanatip Tantivatana 4. Kanyarat Katanyoo |
| Title | Estrogen, Progesterone and Her-2 Receptors Status in Breast Cancer Patients |
| Publisher | Text and Journal Publication |
| Publication Year | 2560 |
| Journal Title | Vajira Medical Journal |
| Journal Vol. | 61 |
| Journal No. | 1 |
| Page no. | 35-43 |
| Keyword | Breast Cancer, estrogen receptor, progesterone receptor, human epidermal growth factorreceptor 2 |
| ISSN | 0125-1252 |
| Abstract | Objective: To study the estrogen receptor (ER), progesterone receptor (PR) and Her-2 Receptor status in breast cancer patients. Methods: Retrospective descriptive study. A total of 437 patients with breast cancer treated in Radiation Oncology Division, Faculty of Medicine Vajira hospital between 1997-2006 were enrolled. Clinical and histological data were assessed from medical records and pathological reports. The results were reported as the expression of Estrogen, Progesterone and Her-2 Receptors status and the factors affecting the expression of all receptors were analyzed. Results: The ER, PR and HER2 were positive in 56.10%, 53.24% and 33.52%, respectively. The proportion of ER+PR+, ER+PR-, ER-PR+, ER-PR- were 46.98 %, 9.56%, 5.46% and 37.2%. Her-2 showed highest positive frequency (17.82%) when both ER and PR were negative. Her-2 showed highest negative frequency (41.37%) when both ER and PR were positive. ER and PR overexpression were associated signifcantly with lower histological grade (p=0.04 and 0.01). Her-2 overexpression was signifcantly associated with higher histological grade (p<0.001) Conclusion: ER and PR positive is the most common status. We found the relationship between the expression of ER, PR and Her-2 receptor status. ER, PR and Her-2 overexpression were associated with histological grade. |
