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Evaluation of tear quantity and quality treated with gintonin eye drops in Labrador retrievers and English springer spaniels |
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| รหัสดีโอไอ | |
| Creator | Joon-Young Kim |
| Title | Evaluation of tear quantity and quality treated with gintonin eye drops in Labrador retrievers and English springer spaniels |
| Contributor | Ji-seung Choi, Soon-wuk Jeong |
| Publisher | Chulalongkorn University |
| Publication Year | 2564 |
| Journal Title | The Thai Journal of Veterinary Medicine |
| Journal Vol. | 51 |
| Journal No. | 1 |
| Page no. | 15 |
| Keyword | Gintonin, Schirmer tear test-1, Tear film break-up time, Tear osmolarity, Tear film quality |
| URL Website | https://he01.tci-thaijo.org/index.php/tjvm/index |
| Website title | https://he01.tci-thaijo.org/index.php/tjvm/index |
| ISSN | 0125-6491 |
| Abstract | The aims of this studywere to determine the relationship between tear osmolarity (TO), Schirmer tear test-1 (STT-1) and tear film break-up time (TBUT) values in canines andto determine the impact ofeye drops containing gintonin -a ginseng-derived lysophosphatidic acid(LPA) receptor ligand -on these indices. Fourteen canines (four English springer spaniels and ten Labrador retrievers) were randomizedinto two groups: the control group received only placeboeye drops (carboxymethylcellulose), while the experimental group received carboxymethylcellulose eye drops containing 5 ?g of gintonin. Treatment was applied twice per day for a period of four weeks and STT-1, TBUTand TO were evaluated both prior to and following the treatment period; the latter using I-PEN?VET (I-MED Animal Health, QC, Canada). Pearson'scorrelation coefficients were calculated to investigate potential associations between baseline TO, STT-1 and TBUT values. Within-group statistical significance of value changes induced by treatment was determined using Student's t-test. Positive correlations exist between TO and STT-1 values, as well as between TO and TBUT values (P = 0.001 and P = 0.032, respectively). Gintonin treatment significantly increased only TBUT (21.0 ? 11.2 s versus 7.5 ? 2.8 s) and TO (317.1 ? 18.1 mOsm/L versus 302.2 ? 19.3 mOsm/L) values (P < 0.01 and P < 0.05, respectively). The results suggest that gintonin improves canine tear film quality, as indicated by increased TBUTand TO values. |
