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Association between Chemiluminescent Microparticle Immunoassay Signal-to-cutoff Ratio and Active Stage of Syphilis in Thai Pregnant Women |
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| รหัสดีโอไอ | |
| Creator | Piyachat Sakunborrirak |
| Title | Association between Chemiluminescent Microparticle Immunoassay Signal-to-cutoff Ratio and Active Stage of Syphilis in Thai Pregnant Women |
| Contributor | Chenchit Chayachinda, Jaruda Kobkitjaroen |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2566 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 31 |
| Journal No. | 4 |
| Page no. | 255-264 |
| Keyword | chemiluminescent microparticle immunoassay, perinatal outcomes, syphilis, screening, signal-to-cutoff ratio |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: To demonstrate the association between chemiluminescent microparticle immunoassay (CMIA) signal-to-cutoff (S/CO) ratio and active stage of syphilis as well as adverse perinatal outcomes. Materials and Methods: A retrospective chart review was conducted in pregnant women with reactive CMIA (CMIA S/CO ratio ? 1) as the primary test in the reverse algorithm of syphilis screening. The participants were categorized into three groups: Group 1 CMIA+ venereal disease research laboratory (VDRL)+; Group 2 CMIA+ VDRL- Treponema pallidumhaemagglutination test (TPHA)+; and Group 3 CMIA+ VDRL- TPHA-. CMIA S/CO ratio and perinatal outcomes were compared. Active stage of syphilis refers to having venereal disease research laboratory (VDRL) titer ? 1:8.Results: Eighty-three out of 8,987 (0.92%) pregnant women who came for antenatal care at Siriraj Hospital between January 2020 and February 2021 were reactive for CMIA. Two twin gestations were excluded. The CMIA S/CO ratio was highest in group 1 (n = 39) at 23.1 ? 5.5, followed by 16.1 ? 5.2 in group 2 (n = 25) and 2.1 ? 3.2 in group 3 (n = 17), p < 0.001. Perinatal outcomes were not different among the groups, except for congenital syphilis (CS). All six neonates with CS were born to the participants in group 1 who had CMIA S/CO ratio ? 19.9. Most of the participants who delivered neonates with CS were diagnosed with syphilis in third trimester and had VDRL titer ? 1:8.Conclusion: Instances of adverse perinatal outcomes and active stage of maternal syphilis were more frequent in pregnant women with higher CMIA S/CO ratio. The use of CMIA S/CO ratio as an adjunct to clinical evaluation may provide additional benefits to the syphilis screening. |
