|
Metoclopramide for Preventing Ileus after Benign Gynecologic Surgery: A randomized controlled trial |
|---|---|
| รหัสดีโอไอ | |
| Creator | Chainarong Sillapasa |
| Title | Metoclopramide for Preventing Ileus after Benign Gynecologic Surgery: A randomized controlled trial |
| Contributor | Rungruedee Jeerasap, Thumwadee Tangsiriwatthana |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2566 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 31 |
| Journal No. | 3 |
| Page no. | 192-200 |
| Keyword | metoclopramide, benign gynecologic surgery, postoperative ileus |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: To assess the efficacy of metoclopramide in preventing ileus after benign gynecologic surgery.Materials and Methods: Participants included were diagnosed with benign gynecologic conditions and scheduled for abdominal hysterectomy at Khon Kaen Hospital between October 2021 and May 2022. Participants were randomly allocated into two groups: the metoclopramide group (n=25) received an injection of 2 ml (10 mg) of intramuscular metoclopramide, while the control group (n=25) received an injection of normal 2 ml of intramuscular saline at 2 h after surgery.Results: The metoclopramide group had significantly less time to first passage of flatus than the control group (placebo) (1,785.3 ? 125.7 vs. 2,186.3 ? 103.0 min, mean difference 401.0 min (95% CI 73.1 to 728.9, p=0.02)). The incidence of ileus symptoms was significantly lower in the metoclopramide group than in the control group (28% vs 68%, p<0.01). Although not statistically significant, the metoclopramide group compared to the control group experienced (a) a shorter time to first defecation and time to tolerate a solid diet, (b) less need for additional antiemetics and additional analgesics, and (c) a shorter length of hospital stay. There were no adverse effects related to the use of metoclopramide in this study.Conclusion: Postoperative intramuscular metoclopramide enhanced the recovery of bowel function after benign gynecologic surgery. |
