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Prevalence and Associated Factors of Positive Margins of Cervical Tissue from Loop Electrosurgical Excision Procedure |
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| รหัสดีโอไอ | |
| Creator | Rawisara Champawong |
| Title | Prevalence and Associated Factors of Positive Margins of Cervical Tissue from Loop Electrosurgical Excision Procedure |
| Contributor | Saowanee Tangmanowuthikul, Surapong Saenpoch, Srisuda Songthamwat, Metha Songthamwat |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2562 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 27 |
| Journal No. | 4 |
| Page no. | 187-194 |
| Keyword | positive margin, loop electrosurgical excision procedure, preinvasive squamous cell carcinoma, cervical intraepithelial neoplasia, carcinoma of cervix |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: The primary objective was to find the prevalence of positive margins of cervical tissue from loop electrosurgical excision procedure (LEEP) for conization and the secondary objective was to determine its associated factors. Materials and Methods: Medical records of 350 patients who underwent LEEP at Udonthani Hospital form March 2016 to July 2018 were reviewed. Data collection included baseline characteristics, preoperative cytology, colposcopic finding, colposcopic directed biopsy histology, histopathological diagnosis, margin of surgical specimens and all related histologic results. The prevalence and associated factors for positive margins were analyzed.Results: There were 323 patients who underwent LEEP and had complete data. The mean age was 42.3 ? 10.6 years. The majority of them had a body mass index < 30 kg/m2 (94.1%), multiparous (88.8%), negative test of human immunodeficiency virus antibody (91.3%) and premenopausal status (76.2%). The prevalence of positive margins of cervical tissue form LEEP was found in 80 cases (24.8%), and the most positive margin site was endocervix (48.8%). From multivariate logistic regression analysis, colposcopic directed biopsy histology > cervical intraepithelial neoplasia 2 was the only significant factor associated with the positive margins (adjusted odds ratio 3.91, 95% confidence interval 1.35-11.27).Conclusion: The prevalence of positive margins of cervical tissue from LEEP was almost one-fourth. The high grade of the colposcopic directed biopsy histology was a significant factor associated with having positive margins. |
