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Association Between Preoperative Serum Markers andLymph Node Metastasis in Endometrioid Adenocarcinomaof Endometrium |
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| รหัสดีโอไอ | |
| Creator | Roseleeya Aleediman |
| Title | Association Between Preoperative Serum Markers andLymph Node Metastasis in Endometrioid Adenocarcinomaof Endometrium |
| Contributor | Kamaitorn Tientong |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2561 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 26 |
| Journal No. | 1 |
| Page no. | 59-67 |
| Keyword | endometrioid adenocarcinoma of endometrium, lymph node metastasis, hemoglobin, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 0857-6084 |
| Abstract | Objectives: Serum markers play many roles in various cancers. Our aim is to investigate whetherpreoperative serum markers can be used for predicting lymph node (LN) metastasis inendometrioid adenocarcinoma of endometrium.Materials and Methods: Clinical characteristics of all patients with pure endometrioid adenocarcinomaof endometrium who underwent complete surgical staging at Rajavithi hospital, between 1January 2010 and 31 December 2014 were retrospectively reviewed. Preoperative serummarkers including hemoglobin (Hb), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio(PLR), multiplication of neutrophil and monocyte counts (MNM), platelet counts, mean plateletvolume (MPV) and serum albumin levels were investigated. Sensitivity, specifiity, positivepredictive value, negative predictive value of serum markers to predict lymph node metastasiswere evaluated.Results: Two hundred eighty-three patients who meet the study inclusion criteria were included.There were 40/283 (14.3%) of LN metastasis. LN metastasis was signifiantly associated withlower Hb level (p < 0.001) and higher NLR, PLR, MNM and platelet count (p = 0.018, p = 0.004,p = 0.008 and p = 0.03 respectively). The best cut off values to identify lymph node metastasiswere 11.85 for Hb (72.5% sensitivity, 59.7% specifiity), 2.29 for NLR (60.0% sensitivity, 61.7%specifiity), 10.37 for PLR (67.5% sensitivity, 56% specifiity), 0.0068 for MNM (70% sensitivity,56% specifiity) and 297,500 for platelet count (62.5% sensitivity, 57% specifiity).Conclusion: Preoperative lower Hb level, higher NLR, PLR, MNM and platelet count were signifiantlyrelated with lymph node metastasis. They could be used in clinical practice to rule in patientswith low risk for LN metastasis without extra costs |
