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The Correlation between Aflatoxin B1 and PlacentalApoptosis in Pregnant Women with Intrauterine GrowthRestriction |
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| รหัสดีโอไอ | |
| Creator | Ahmed M. Abbas, M.D. |
| Title | The Correlation between Aflatoxin B1 and PlacentalApoptosis in Pregnant Women with Intrauterine GrowthRestriction |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2559 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 24 |
| Journal No. | 2 |
| Page no. | 104-116 |
| Keyword | apoptosis, afltoxin B1, caspase-3, IUGR, placenta |
| ISSN | 0857-6084 |
| Abstract | Objective: To explore the effect of Afltoxin B1 toxicity as a risk factor of intrauterine growthrestriction (IUGR) and to determine the role of placental apoptotic indices in the pathogenesisof IUGR and their association with maternal risk factors including residency, working andexposure to smoking.Materials and Methods: A case-control study was done at Women Health Hospital; Assiut University,Egypt. Sixty pregnant women with asymmetrical IUGR and a control group of 40 normalpregnancies were selected. Maternal urine samples were obtained for Afltoxin B1 levelmeasurement by layer chromatography. Quantitative determination of human placental Bcl-2and caspase-3 using a monoclonal antibody-based enzyme-linked immunosorbent assay kitswere performed.Results: The results showed that afltoxin B1 positive cases in the IUGR group had signifiantlyhigher placental caspase-3 and lower placental Bcl-2 concentrations than those which wereafltoxin B1 negative (p<0.01). The levels of placental apoptotic indices were higher in workingwomen who lived in urban areas and those exposed to cigarette smoke than non-working womenwho lived in rural areas and non-smokers.Conclusions: Afltoxin B1 may affect the fetal growth by increasing the placental apoptosis. Theseresults may highlight the importance of afltoxin B1 which may contribute to the complex etiologyof IUGR. Placental apoptotic indices levels were signifiantly affected by maternal residence,working and exposure to smoking in pregnancies complicated with IUGR. |
