|
Comparison of Sublingual and Vaginal Misoprostol forCervical Ripening before Curettage: A RandomizedControlled Trial |
|---|---|
| รหัสดีโอไอ | |
| Creator | Sukanya Chamnan, M.D., |
| Title | Comparison of Sublingual and Vaginal Misoprostol forCervical Ripening before Curettage: A RandomizedControlled Trial |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2559 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 24 |
| Journal No. | 1 |
| Page no. | 43-49 |
| Keyword | Misoprostol, cervical dilatation, local anesthesia |
| ISSN | 0857-6084 |
| Abstract | Objective: To compare the effectiveness and side effects of misoprostol as a cervical ripeningagent through two different routes of administration before curettage.Materials and Methods: The study employed a hospital based prospective randomized controlledtrial. A total of 70 patients were simple random divided in two groups for 400 microgramssublingual and vaginal administration. The drug was administered 6 hours before dilatation andcurettage or fractional curettage. Efficacy was assessed on cervical dilatation achieved, painscore and vaginal blood loss. The tolerable limit was noted based on side effects.Results: The sublingual group had signifiantly more cervical dilatation than the vaginal group(median cervical dilatation 7 mm vs. 5 mm, P < 0.001). Signifiantly less pain scores (VAS) insublingual group than vaginal group (3.3 vs. 4.8, P < 0.001). Postoperative vaginal blood lossin the sublingual group was signifiantly greater than the vaginal group (20 ml vs. 10 ml,P < 0.001). Other side effects such as fever, chill, nausea, vomiting and diarrhea did not differin both groups.Conclusion: Sublingual misoprostol could be more effective for cervical dilatation, but presentsgreater postoperative vaginal blood loss than vaginal route. |
