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Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion |
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| รหัสดีโอไอ | |
| Creator | Palaporn Kanjanasirirut |
| Title | Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion |
| Contributor | Kamol Pataradool, Sumonmal Manusirivithaya, Chadakarn Phaloprakarn, Chutima Chavanisakun |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2558 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 23 |
| Journal No. | 4 |
| Page no. | 240-245 |
| Keyword | HSIL, positive margin, LEEP |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 0857-6084 |
| Abstract | Objective: To determine the prevalence and risk factors for positive surgical margin after LEEP in patients with high grade squamous intraepithelial lesion (HSIL). Material and Methods: Medical records of all women (n = 575) who underwent LEEP and histopathological diagnosed HSIL between January 2008 and December 2012 in our institution were reviewed. The margins of surgical specimens were re-evaluated by a pathologist. Clinical data and status of surgical margin were recorded. The prevalence and risk factors for positive surgical margin were analyzed. Results: Complete data of 547 women with HSIL who underwent LEEP were obtained. Mean age of the women was 41.8 ? 12.5 years (ranging from 17 to 75 years). The majority of them were multiparous (n = 405 or 74.1%) and premenopause (n = 464 or 84.8%). Positive LEEP surgical margin was found in 167 cases (30.5 %). In multivariable analysis, multiparity and glandular involvement were two independent risk factors for positive LEEP surgical margin; adjusted relative risk of 8.10 (95% confidence interval, 3.82-17.20) and 14.10 (95% confidence interval, 8.34-23.83), respectively.Conclusions: The prevalence of positive margin in women with HSIL who underwent LEEP was 30.5%. Multiparity and glandular involvements were significant factors associated with the margin involvement. |
