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การศึกษาความแปรผันของยีน CDKN2A/2B, CDKAL1, HHEX, KCNQ1, MTNR1B, SLC30A8, TCF7L2 และ UBE2E2 กับการเกิดโรคเบาหวานชนิดที่สองในประชากรไทย (Study of Common Variations of CDKN2A/2B, CDKAL1, HHEX, KCNQ1, MTNR1B, SLC30A8,TCF7L2 and UBE2E2 and Type 2 Diabe |
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| รหัสดีโอไอ | |
| Creator | ศุภนันท์ บุตรแก้ว |
| Title | การศึกษาความแปรผันของยีน CDKN2A/2B, CDKAL1, HHEX, KCNQ1, MTNR1B, SLC30A8, TCF7L2 และ UBE2E2 กับการเกิดโรคเบาหวานชนิดที่สองในประชากรไทย (Study of Common Variations of CDKN2A/2B, CDKAL1, HHEX, KCNQ1, MTNR1B, SLC30A8,TCF7L2 and UBE2E2 and Type 2 Diabetes (T2D) in Thais) |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2556 |
| Journal Title | Thai Journal of Genetics |
| Journal Vol. | S.1 |
| Journal No. | S1 (Special Issue 1) |
| Page no. | 167 |
| Keyword | Type 2 Diabetes, single nucleotide polymorphism, genome wide association study, HRM analysis, RFLP |
| ISSN | 8578664 |
| Abstract | Several type 2 diabetes mellitus (T2D) susceptibility loci identified through genome-wide association studies (GWAS) have been replicated in various populations. However, such study has not been done in Thais. This study was to investigate the effect of CDKN2A/2B (rs10811661), CDKAL1 (rs7754840, rs7756992), HHEX(rs7923837, rs5015480, rs1111875), KCNQ1 (rs2237892, rs2237895, rs2238228, rs2237897), MTNR1B(rs1387153, rs10830963), SLC30A8 (rs13266634), TCF7L2 (rs7903146, rs7895340, rs11196205) and UBE2E2(rs6780569, rs7612463) and risk of T2D in Thais. We genotyped 18 single nucleotide polymorphisms (SNPs) of 8 genes in 516 patients with T2D and 511 non-diabetic controls by high resolution melting analysis (HRM) and restriction fragment length polymorphism (RFLP). SNPs of KCNQ1, CDKN2A/2B, HHEX, SLC30A8 and TCF7L2were significantly associated with T2D. Moreover, haplotype analysis of KCNQ1, HHEX and TCF7L2 were likewise associated with the disease. We also demonstrated the relationship between SNPs of KCNQ1 and fasting plasma glucose (FPG), HbA1c, total cholesterol and low-density lipoprotein cholesterol (LDL-C). The correlation between SNPs of CDKN2A/2B and FPG were also observed. Our findings have suggested that KCNQ1, CDKN2A/2B,HHEX, SLC30A8 and TCF7L2 play a role of in the pathogenesis of T2D in Thai population. |
