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การศึกษายีน CYP2D6 และ HLA-B*15:02 ในเด็กไทยที่มีภาวะออทิสติกสเปคตรัมเพื่อความเหมาะสมในการรักษาและการตรวจวิเคราะห์ทางเภสัชพันธุศาสตร์ (Molecular Genetic Analysis of CYP2D6 and HLA-B*15:02 in Thai Autistic Spectrum Disorder Children: Implication of Phar |
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| รหัสดีโอไอ | |
| Creator | พงษ์วุฒิ สุวรรณรัตน์ |
| Title | การศึกษายีน CYP2D6 และ HLA-B*15:02 ในเด็กไทยที่มีภาวะออทิสติกสเปคตรัมเพื่อความเหมาะสมในการรักษาและการตรวจวิเคราะห์ทางเภสัชพันธุศาสตร์ (Molecular Genetic Analysis of CYP2D6 and HLA-B*15:02 in Thai Autistic Spectrum Disorder Children: Implication of Pharmacogenetics Testing and Optimization of Drug Treatments) |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2556 |
| Journal Title | Thai Journal of Genetics |
| Journal Vol. | S.1 |
| Journal No. | S1 (Special Issue 1) |
| Page no. | 406 |
| Keyword | autistic spectrum disorders, CYP2D6, HLA-B*1502, genetic polymorphisms, adverse drug reactions |
| ISSN | 8578664 |
| Abstract | Genetic polymorphisms of CYP2D6 and HLA-B have been associated with efficacy and toxicity variation of various antipsychotic drugs including those for autistic spectrum disorder (ASD). The objective of this study is to investigate and compare allele frequency of CYP2D6 and HLA-B*1502 between 292 Thai ASD patients and 781 non-ASD. The genetic variants of CYP2D6 and HLA-B*1502 were investigated by microarray technique and RT-PCR based method. The most common allele frequency of CYP2D6*10, *1 and *2 in ASDs group were 54.43% (86/158), 22.78% (36/158) and 11.39% (18/158), respectively and non-ASDs were 44.18% (138/308), 26.30% (81/308) and 7.47% (23/308), respectively. The frequencies of HLA-B*1502 in ASD and Non-ASD were 14.72% (43/292) and 14.19% (89/627). No statistically significant difference between investigated allele frequency of ASD and Non-ASD group. This is the first study of the CYP2D6 and HLA-B*1502 gene polymorphisms in Thai autistic spectrum disorder patients. This information may be useful to determine the appropriate treatment for Thai autistic spectrum disorder. |
