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Cancer: secret in genetic code and DNA mismatch repair genes. Abnomalities of these genes can be both from mutations and epigenetics. However, cancer is not a single gene disorder. Tumorigenesis is a lengthy process and several gene mutations need to |
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| รหัสดีโอไอ | |
| Creator | 1. Pattamawadee Yanatatsaneejit 2. Suphakit Khowutthitham |
| Title | Cancer: secret in genetic code and DNA mismatch repair genes. Abnomalities of these genes can be both from mutations and epigenetics. However, cancer is not a single gene disorder. Tumorigenesis is a lengthy process and several gene mutations need to accumulate for a long time for cancer to develop. Nowadays, pharmacogenetics has been used in cancer therapy. For example, drug therapy for EGFR mutation has been used for lung cancer patients. Therefore, knowledge from genetic study can be applied in clinical development for improving quality of human life. |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2555 |
| Journal Title | Thai Journal of Genetics |
| Journal Vol. | 5 |
| Journal No. | 1 |
| Page no. | 120 |
| Keyword | cancer, risk factor, DNA and chromosome, mutation, epigenetics |
| ISSN | 8578664 |
| Abstract | Cancer is one of the leading causes of death in human, resulting in abnormal cell growth. The causes of this abnormality are both environmental and genetics leading to DNA damage, mutation and ultimately cancer cells. Cancer genes can be categorized into 3 groups; oncogenes, tumor suppressor genes |
