|
Noncanonical functions of lysyl-tRNA synthethase in HIV-1 packaging |
|---|---|
| รหัสดีโอไอ | |
| Creator | Nonlawat Boonyalai |
| Title | Noncanonical functions of lysyl-tRNA synthethase in HIV-1 packaging |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2554 |
| Journal Title | Thai Journal of Genetics |
| Journal Vol. | 4 |
| Journal No. | 1 |
| Page no. | 31 |
| Keyword | lysyl-tRNA synthetase, diadenosine polyphosphate, HIV-1 capsid protein, HIV-1 packaging |
| ISSN | 8578664 |
| Abstract | Lysyl-tRNA synthetase (LysRS) catalyzes the formation of Lys-tRNALys. Addition to its role in the translation apparatus, LyRS has other alternative functions which are of great interest. LysRS involves in the production of diadenosine tetraphosphate, acts as a cytokine-like molecule and play a major role in HIV-1 packaging. Interestingly, reverse transcription of the HIV-1 genome is primed by a human tRNALys3 which is packaged into the virion by the HIV-1 Gag and LysRS. However, the structural basis for simultaneous packaging of tRNALys3, LysRS and Gag is still not understood. Better understanding of the interaction among tRNALys3, LysRS and Gag might open the way for the design and screening of small peptides and/or other small molecules capable of potentially interfering with the HIV-1 life cycle by blockading interactions between LysRS and the Gag CA-C domain. |
