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PORCINE PLACENTA EXTRACT-LOADED MATRIX POLYMERIC-BASED DISSOLVING MICRONEEDLES FOR IMPROVING SKIN HYDRATION |
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| รหัสดีโอไอ | |
| Creator | Pattaranut Eakwaropas |
| Title | PORCINE PLACENTA EXTRACT-LOADED MATRIX POLYMERIC-BASED DISSOLVING MICRONEEDLES FOR IMPROVING SKIN HYDRATION |
| Contributor | Kritsanaporn Tansathien, Worranan Rangsimawong, Praneet Opanasopit |
| Publisher | Faculty of pharmacy, Silpakorn University |
| Publication Year | 2565 |
| Journal Title | Thai Bulletin of Pharmaceutical Sciences |
| Journal Vol. | 17 |
| Journal No. | 2(July-December)2022 |
| Page no. | 69-82 |
| Keyword | dissolving microneedle, porcine placenta, polyvinylpyrrolidone, polyvinyl alcohol, hyaluronic acid, skin hydration |
| URL Website | https://li01.tci-thaijo.org/index.php/TBPS |
| ISSN | 2586-8659 |
| Abstract | Porcine placenta extract (PPE) is a macromolecular substance, that affects the limitation of permeability through the skin. The aim of this study was to fabricate matrix polymeric-based dissolving microneedles (DMNs) loaded with PPE for improving skin conditions. DMNs were developed by a mold-based method using polyvinylpyrrolidone K90, polyvinyl alcohol, and hyaluronic acid at a weight ratio of 2:0.5:1. The DMNs properties such as the morphology, PPE loading efficiency and capacity, the mechanical strength, skin insertion, in vitro dissolution, in vitro skin permeation, and stability were analyzed. Then, the in vivo human study was also evaluated to reveal the safety and effectiveness of PPE-loaded DMNs. The results showed that 3% w/w of PPE-loaded DMNs had a suitable morphology, good mechanical properties, complete insertion, and rapid dissolution into the skin. These DMNs exhibited high skin permeability of entrapped macromolecular protein. In the stability test, the DMNs showed a total protein content of over 80% at storage for a month in all temperatures. For in vivo human study, no skin irritation was found. Transepidermal water loss values increased, referring to the micro-holes created by DMNs for delivering PPE. Additionally, the PPE-loaded DMNs significantly increased skin hydration. Therefore, the good physical properties of 3% w/w PPE-loaded DMNs play an important role to enhance the PPE penetration through the skin and provide effective skin hydration without skin irritation. |
