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Preparation, Characterization and Antibacterial Study of Novel 2-[5-(4-Chlorophenyl)-4, 5-dihydro-1, 2-oxazol-3-yl] Compounds |
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| รหัสดีโอไอ | |
| Creator | Kiran V. Mehta |
| Title | Preparation, Characterization and Antibacterial Study of Novel 2-[5-(4-Chlorophenyl)-4, 5-dihydro-1, 2-oxazol-3-yl] Compounds |
| Publisher | Silpakorn University Research and Development Institute |
| Publication Year | 2559 |
| Journal Title | Silpakorn University Science and Technology Journal |
| Journal Vol. | 10 |
| Journal No. | 1 |
| Page no. | 27-31 |
| Keyword | 1,2-oxazol-3-yl, Synthesis, Structure, Antibacterial. |
| ISSN | 1905-9159 |
| Abstract | This research paper describes a study about synthesis, structure determination and antibacterial activity evaluation of some novel heterocyclic compounds having 2-[5-(4-chlorophenyl)-4,5-dihydro-1,2-oxazol-3-yl] fragment. To prepare this kind of compounds, 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one was prepared. Its coupling reaction was carried out with diazonium salt of 1o aromatic amine. The coupled product was separated and reacted with hydroxylamine hydrochloride. The final product containing 2-[5-(4-chlorophenyl)-4,5-dihydro-1,2-oxazol-3-yl] fragment was characterized with the help of melting point determination and elemental analysis of carbon, hydrogen, nitrogen and chlorine elements. Further characterization was performed with the help of IR, 1 H NMR and Mass spectroscopic methods. The characterization study supports the projected structures of heterocyclic derivatives. Antibacterial assay in vitro for these compounds was carried out for Pseudomonas aeruginosa, Bacillus subtilis, Erwinia carotovora and Escherichia coli. It showed good antibacterial activity. |
