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Clinical Outcomes and Risk Factors Affecting 30-day Mortality and Treatment Failure of Patients Infected with Carbapenem-Resistant Acinetobacter baumanii in a General Hospital |
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| รหัสดีโอไอ | |
| Creator | 1. Wichai Santimaleeworagun 2. Wandee Sumret 3. Kanokwan Limsubjaroen 4. Nattaporn Ruangnara 5. Parada Sujarittham 6. Ploypailin Mulmek 7. Weerayuth Saelim |
| Title | Clinical Outcomes and Risk Factors Affecting 30-day Mortality and Treatment Failure of Patients Infected with Carbapenem-Resistant Acinetobacter baumanii in a General Hospital |
| Publisher | Silpakorn University Research and Development Institute |
| Publication Year | 2557 |
| Journal Title | Silpakorn University Science and Technology Journal |
| Journal Vol. | 8 |
| Journal No. | 1 |
| Page no. | 9 - 17 |
| Keyword | Acinetobacter baumannii, Carbapenem-resistant, Clinical outcomes, Risk factors |
| ISSN | 1905-9159 |
| Abstract | This study aimed to determine 30-day mortality and treatment failure rates in patients infected with carbapenem-resistant Acinetobacter baumanii (CRAB) and to evaluate predictive factors associated with 30-day mortality and treatment failure. This retrospective study collected data from medical records of patients admitted to Hua Hin Hospital from January to December, 2012. Seventy- three patients with CRAB infections met the eligible criteria, while 57.5 and 61.6 % were death and treatment failure rate, respectively. Risk factors associated with 30-day mortality were appropriate antimicrobial therapy (OR 0.22; 95% CI 0.08-0.62) and shock (OR 5.80; 95% CI 1.19-28.20). In addition, the appropriate antimicrobial therapy (OR 0.11; 95% CI 0.03 0.37) and shock (OR 10.97; 95% CI 1.35 89.34) were also predictors for treatment failure. In multivariate analysis, a factor associated with 30-day mortality and treatment failure remained the appropriate antimicrobial therapy. In conclusion, the appropriate antimicrobial treatment was a strategy associated with better treatment outcomes in patients with CRAB infections. |
