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Preparation, Characterization and Antiradical Activity of Zinc Oxide Nanoparticles |
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| รหัสดีโอไอ | |
| Creator | Kanyarat Kumnoedauy |
| Title | Preparation, Characterization and Antiradical Activity of Zinc Oxide Nanoparticles |
| Contributor | Pattareeya Damrongsak, Kitsakorn Locharoenrat, Badin Damrongsak |
| Publisher | Faculty of Science and Technology, Suan Sunandha Rajabhat University |
| Publication Year | 2565 |
| Journal Title | Suan Sunandha Science and Technology Journal |
| Journal Vol. | 9 |
| Journal No. | 2 |
| Page no. | 1 to 7 |
| Keyword | Antiradical, DPPH, Sol-gel, ZnO nanoparticles |
| URL Website | http://www.ssstj.sci.ssru.ac.th/ |
| Website title | Suan Sunandha Science and Technology Journal (SSSTJ) |
| ISSN | 2351-0889 |
| Abstract | Zinc oxide nanoparticles (ZnO NPs) have recently been studied as a multi-functional and multi-targetnanomedicine for cancer treatment. They can be used not only as a nanocarrier for delivery of the chemotherapydrug but also as an antiradical agent due to their photo-catalytic and photo-oxidizing abilities. Our previous workshowed a potential use of commercial-available ZnO NPs without and with carboplatin for the treatment ofretinoblastoma. The aim of this work was to synthesize ZnO NPs having smaller particle size than the commercialones, i.e., 100 nm average diameter, in order to improve the reaction time. ZnO NPs were prepared by a sol-geltechnique and calcined with different calcination conditions. The structure and particle size of ZnO powders werecharacterized using an x-ray diffractometer and a particle size analyzer. Average nanoparticle sizes of 16.32 ?1.64 nm were achieved at a calcination temperature of 300 degree Celsius and 1 hour holding time. The antiradicalactivity of prepared ZnO NPs in cooperation with ultraviolet irradiation was assessed using a putative model ofcancer cells, i.e., 2,2(diphenyl-1-picryhydrazyl) radicals (DPPH*). An optical spectroscopy was used to detect thedecrease in peak absorbance of the antiradical solution at a wavelength of 515 nm, which in turn can be used tocalculate the percent remaining of DPPH*. The disappearance of DPPH* with respect to the reaction time revealedthat prepared ZnO NPs (16.32 ? 1.64 nm) improved response time as compared with ZnO NPs (100 nm).Moreover, the effective ZnO concentrations to reduce the initial DPPH* concentration by 50%, also known as theEC50 value in the present study, is lower indicating the improvement of anti-proliferative activity when comparedto the commercial ZnO NPs |
