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MESOSCALE SIMULATION ON SELF-ASSEMBLING BEHAVIOR OF POLY(ETHYLENEOXIDE)-POLY(PROPYLENE OXIDE)-POLY (ETHYLENE OXIDE) TRIBLOCK COPOLYMER MICELLE |
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| รหัสดีโอไอ | |
| Creator | 1. Mantana Chansuna 2. Nuttaporn Pimpha 3. Visit Vao-soongnern |
| Title | MESOSCALE SIMULATION ON SELF-ASSEMBLING BEHAVIOR OF POLY(ETHYLENEOXIDE)-POLY(PROPYLENE OXIDE)-POLY (ETHYLENE OXIDE) TRIBLOCK COPOLYMER MICELLE |
| Publisher | Suaranaree University of Technology |
| Publication Year | 2557 |
| Journal Title | Suranaree Journal of Science and Technology |
| Journal Vol. | 21 |
| Journal No. | 3 |
| Page no. | 249-257 |
| Keyword | Triblock copolymer, polymer micelle, mesoscale simulation |
| ISSN | 0858849X |
| Abstract | The aggregation and phase behavior of a Poly (ethylene oxide)-Poly (propylene oxide)-Poly (ethylene oxide), (PEO-PPO-PEO) triblock copolymer model was investigated by field-based mesoscale simulation (MesoDyn). The effects of the propylene oxide/ ethylene oxide (PPO/PEO) block ratio, copolymer concentrations, and adding a hydrophobic drug moleculeon the morphology of the polymer aggregation were studied. The results show that with increasing the polymer concentration, polymer aggregations of different types were obtained i.e. spherical micelle, disk-like micelle, wormlike micelle, and biphase. For a higher PPO/PEO block ratio, a lower critical micelle concentration (cmc) and larger micelle size were observed. Adding the hydrophobic drug i.e. haloperidol into the solution induced the spherical micelle to form more easily and the micelle sizeto become larger. Haloperidol was located at the interface between the PEO and PPO components. |
