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Using design of experiments to fabricate nanostructured lipid carrierof egg white hydrolysates |
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| รหัสดีโอไอ | |
| Creator | 1. Nisachon Jangpromma 2. Supisara Jearranaiprepame 3. Boonpob Nowichai 4. Sirinthip Sosiangdi 5. Watcharee Khunkitti |
| Title | Using design of experiments to fabricate nanostructured lipid carrierof egg white hydrolysates |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2565 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 44 |
| Journal No. | 2 |
| Page no. | 517-523 |
| Keyword | nanostructured lipid carriers, design of experiment, egg white hydrolysates, delivery, skin barrier |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | The aims of this study were to develop a nanostructured lipid carrier (NLC) system and optimize an appropriate NLCformulation using design of experiments (DOE). The results showed that the formulation containing glycerol monostearate(GMS) 0.35 g, stearic acid (SA) 0.50 g and isopropyl myristate (IPM) 0.65 g was optimal with entrapment efficiency (%EE)(59.21%), particle size (233.7nm) and zeta potential (-41.26 mV). Moreover, solid lipid (GMS, SA) and liquid lipid (IPM) hadsignificant impact on NLC characteristics. The positive effect on the %EE was due to the interaction between GMS and IPM, andSA and IPM. The optimal formulation EWH-NLC at concentration 125 ยตg/ml expressed the highest inhibitory activity againstNO production in RAW 264.7 macrophages with no cytotoxicity. The release profile of EWH-NLC in the cream base exhibitedsustained release behavior that best fitted with Higuchi model. These results suggest that the NLC is a suitable carrier for EWHin topical application with a sustained-release profile. |
