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In vitro evaluation of wound healing potential of sulfated galactansfrom red alga Gracilaria fisheri in fibroblast cells |
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| รหัสดีโอไอ | |
| Creator | 1. Choowadee Pariwatthanakun 2. Tawut Rudtanatip 3. Boonyakorn Boonsri 4. Benjamart Pratoomthai 5. Kanokpan Wongprasert |
| Title | In vitro evaluation of wound healing potential of sulfated galactansfrom red alga Gracilaria fisheri in fibroblast cells |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2564 |
| Journal Title | Songklanakarin Journal of Science an Technology (SJST) |
| Journal Vol. | 43 |
| Journal No. | 5 |
| Page no. | 1374-1381 |
| Keyword | sulfated galactans, red alga, fibroblast, wound healing, collagen production |
| URL Website | https://rdo.psu.ac.th/sjst/index.php |
| ISSN | 0125-3395 |
| Abstract | Red alga Gracilaria species have been reported various to exhibit significant pharmacological activities. In this study,sulfated galactans (SG) from G. fisheri was investigated for its potential activity in wound healing using in vitro approach. L929fibroblast cells were treated with different concentrations of SG and wound healing activity and collagen content determined.Expression of the specific mRNA transcripts and translated proteins was assessed. In a scratch wound healing culture, SGenhanced the rate of migration of the fibroblast cells, accompanied by increased expression of integrin ?1, p-FAK, p-NF-?B, Ecadherin proteins, and the active form of MMP-2. In addition, SG increased expression of COL1A1 mRNA and protein andstimulated collagen production. In conclusion, this study demonstrates that SG from G. fisheri promotes would healing offibroblasts, in part, through integrin-FAK and NF-?B-MMP signaling pathways. This suggests that SG could be a promisingcompound for further investigation of its potential on wound treatment. |
