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In vitro method for studying the penetration of cinnamon oiland chlorhexidine through Candida albicans biofilmusing Franz diffusion apparatus |
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| รหัสดีโอไอ | |
| Creator | 1. Panitta Satthanakul 2. Suwimol Taweechaisupapong 3. Somkiat Luengpailin 4. Watcharee Khunkitti |
| Title | In vitro method for studying the penetration of cinnamon oiland chlorhexidine through Candida albicans biofilmusing Franz diffusion apparatus |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 2 |
| Page no. | 248-254 |
| Keyword | Candida albicans, biofilm penetration study, chlorhexidine, cinnamon oil, Franz diffusion apparatus |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Biofilm extracellular polymeric substances can act as a barrier to antifungal agents reaching the target site of yeast cellsin the basal layer which results in resistance to various antifungal drugs. The aim of this study was to use a Franz diffusionapparatus to investigate the penetration of cinnamon oil and chlorhexidine (CHX) in various combinations through a Candidaalbicans biofilm. This study demonstrated that 0.5% (w/v) CHX and in combination with cinnamon oil solution (8 ?L/mL)penetrated the C. albicans biofilm. In addition, sessile C. albicans biofilms exposed to 0.5% (w/w) CHX and in combination withcinnamon oil (8 ?L/mL) for 4 h resulted in log reductions. In conclusion, this in vitro method may be used to investigate thepenetration of antimicrobial solutions through C. albicans biofilm qualitatively and quantitatively at timed intervals. |
