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Yakae-Prajamduen-Jamod recipe reduced anxiety behaviorand brain oxidative damage in ovariectomized mice |
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| รหัสดีโอไอ | |
| Creator | 1. Ariyawan Tantipongpiradet 2. Orawan Monthakantirat 3. Supawadee Daodee 4. Chantana Boonyarat 5. Kinzo Matsumoto 6. Supaporn Pitiporn 7. Yaowared Chulikhit |
| Title | Yakae-Prajamduen-Jamod recipe reduced anxiety behaviorand brain oxidative damage in ovariectomized mice |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 1 |
| Page no. | 172-179 |
| Keyword | ABP, menopause, ovariectomy, anxiety, lipid peroxidation |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Yakae-Prajamduen-Jamod (ABP), which was acquired from Chao Phraya Abhaibhubejhr Hospital, is a traditional Thaiherbal formula to treat perimenopausal and menopausal symptoms. However, its mechanism remains unknown. The presentstudy aimed to investigate the effects of ABP on ovariectomy-induced anxiety and oxidative stress in mice. Ovariectomized miceexhibited not only anxiety in elevated plus maze and mirror chamber tests, but also brain oxidative stress when compared withcontrol. Ovariectomy-induced behavioral and neurochemical alterations were attenuated by ABP treatment (500 mg/kg/day). Wealso analyzed antioxidant activities of ABP using DPPH and ABTS assays. ABP showed radical scavenging activity with IC5058.59 and 44.99 ?g/mL, respectively. Total phenolic and flavonoid contents were 110.53?1.50 mg GAE and 152.25?0.5 mg rutinequivalents per gram extract, respectively. These findings suggest that ABP attenuated the ovariectomy-induced anxiety andoxidative brain injury via antioxidative properties. Therefore, ABP is an alternative choice of anxiety disorder in the menopausaltransition. |
