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Early-life exposure to omega-9 monounsaturated fatty acidresults in gonadal-regression and elevated stress levelsin pubertal male rat |
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| รหัสดีโอไอ | |
| Creator | 1. Oluwakemi Tinuolaoluwa Oyelowo 2. Adeyombo Folashade Bolarinwa |
| Title | Early-life exposure to omega-9 monounsaturated fatty acidresults in gonadal-regression and elevated stress levelsin pubertal male rat |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 6 |
| Page no. | 1248-1252 |
| Keyword | omega-9, corticosterone, testosterone, prolactin |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Corticosterone decreases hormones in the hypothalamic-pituitary-gonadal axis in stressful situations as well as whennutritional factors are modulated. The effect of in-utero exposure to omega-9 fatty acid on the gonadal hormones were comparedwith corticosterone in pubertal male rats. Pregnant rats were distributed on a random basis into five groups of five rats each asfollows: F0C: the control group was administered 1ml/kg of olive oil; F0EXBM was administered 1000mg/kg of oleic acid for7days before mating; F0GD1-7 was administered 1000mg/kg of oleic acid from gestation day (GD)1-7; F0GD8-15 was administered1000mg/kg of oleic acid from GD8-15. At puberty, hormonal analysis was carried out. Testicular prolactin, testosterone, folliclestimulating and luteinizing hormone levels were decreased while corticosterone level was increased. Since corticosterone levelsmay adversely affect the male reproductive system, omega-9 fatty acid should be considered as a possible contributing factor inany decline of male fertility rates. |
