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Changes of dopamine D2, alpha1 adrenergic receptor expressionsand developmental stages of seminiferous tubule in rat testisafter methamphetamine administration: A preliminary study |
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| รหัสดีโอไอ | |
| Creator | 1. Samur Thanoi 2. Siriporn Janphet 3. Sutisa Nudmamud-Thanoi |
| Title | Changes of dopamine D2, alpha1 adrenergic receptor expressionsand developmental stages of seminiferous tubule in rat testisafter methamphetamine administration: A preliminary study |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 4 |
| Page no. | 928-934 |
| Keyword | Methamphetamine, dopamine D2 receptor, adrenergic receptor, spermatogenesis, seminiferous epithelium |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | The alterations of dopamine D2 receptor (D2R) and ?1 adrenergic receptor (?1AR) expressions and developmentalstages of seminiferous tubule were investigated in twenty-two male rats that underwent one of three Methamphetamine (METH)treatment regimes: acute binge (AB), escalating dose (ED) or escalating binge dose (ED-binge), in comparison with the control.The percentages of stage II seminiferous tubule were significantly decreased in ED and ED-binge groups. Reductions of D2Rimmunoreactivity in spermatocytes were found in all METH treated groups, while D2R reductions in elongated spermatids werefound in ED and ED-binge groups. The expressions of ?1AR in spermatocytes were increased in all METH treated groups aswell as in round and elongated spermatids in ED and ED-binge groups. The results indicate that METH can cause changes inD2R and ?1AR expressions in the testis of METH-addicted rats, which may disrupt DA and NE functions leading to changes ofseminiferous epithelium development and consequently spermatogenesis impairment. |
