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Discovery of COVID-19ProteinInhibitorsin Phenolic Acids of Azadirachta indica(Neem) usingDocking and Pharmacokinetics |
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| รหัสดีโอไอ | |
| Creator | Mohd Fadhlizil Fasihi Mohd Aluwi |
| Title | Discovery of COVID-19ProteinInhibitorsin Phenolic Acids of Azadirachta indica(Neem) usingDocking and Pharmacokinetics |
| Contributor | Miah Roney, AKM Moyeenul Huq |
| Publisher | Research Administration Division |
| Publication Year | 2567 |
| Journal Title | Science & Technology Asia |
| Journal Vol. | 29 |
| Journal No. | 3 |
| Page no. | 290-303 |
| Keyword | Anti-COVID-19, Azadirachta indica, Docking, Phenolic acid, Pharmacokinetics |
| URL Website | https://www.tci-thaijo.org/index.php/SciTechAsia/index |
| Website title | ThaiJo2 |
| ISSN | 2586-9000 |
| Abstract | COVID-19, a viral infectioncaused by the coronavirus SARS-CoV-2, is one of the world's most challenging diseases to cure. The fact that COVID-19 does not currently have any pharmaceuticaltreatmentsmeans that a concentrated effort must be made to discover the much-needed remedies for this illness. The most attractive antiviral targets of SARS-CoV-2are the spike protein and main protease (Mpro). In this work, sixteen phenolic acids of Azadirachta indica were docked into the active site of the spike protein and Mpro. The resulting compounds were then subjected to pharmacokinetic studies to establish thelead compounds. Based on the results, ferulic acid was found to be a promising candidate for further research into its potential as aSARS-CoV-2inhibitor due to its positiveanticipated pharmacokinetics and pharmacological properties. |
