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Modeling the effect of drug therapy on hepatitis B virus infection |
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| รหัสดีโอไอ | |
| Creator | Pensiri Yosyingyong |
| Title | Modeling the effect of drug therapy on hepatitis B virus infection |
| Contributor | Ratchada Viriyapong |
| Publisher | Division of Research Facilitation and Dissemination Mahasarakham University |
| Publication Year | 2561 |
| Journal Title | RESEARCH & KNOWLEDGE |
| Journal Vol. | 4 |
| Journal No. | 1 |
| Page no. | 26-32 |
| Keyword | Hepatitis B virus, cytotoxic T lymphocytes, hepatocyte, sensitivity, drug therapy |
| URL Website | https://rk.msu.ac.th/ |
| Website title | Research&Knowledge |
| ISSN | 2408-204X |
| Abstract | With an increase in hepatitis B virus (HBV) infection every year around the world,particularly in developing countries, a mathematical model involving the relationship between HBVand the cytotoxic T lymphocytes (CTL)-mediated immunity is constructed. The model also includesnon-cytolytic cure process and drug therapy of HBV. The basic reproduction number R0 is calculatedand becomes threshold for equilibrium point stabilities. Sensitivity analysis is carried out to seek forpotential parameters that could reduce overall spread of HBV infection. The numerical and sensitivityanalyses show that both effectiveness of drug therapy in blocking new infection and non-cytolytic cureprocess play a key role in reducing the concentration of infected hepatocytes and free virus. Therefore,HBV drug therapy should be encouraged as one of the approaches to reduce overall chronic HBVinfection. |
