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Prevalence and related factors for injectable vancomycin or teicoplanin-associated thrombocytopenia in a Vietnamese hospital |
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| รหัสดีโอไอ | |
| Creator | 1. HT. Nguyen 2. T. Pham 3. HT. Bui |
| Title | Prevalence and related factors for injectable vancomycin or teicoplanin-associated thrombocytopenia in a Vietnamese hospital |
| Publisher | Faculty of Pharmacy, Mahidol University |
| Publication Year | 2558 |
| Journal Title | Mahidol University Journal of Pharmaceutical Sciences |
| Journal Vol. | 42 |
| Journal No. | 4 |
| Page no. | 178-185 |
| Keyword | vancomycin injection,teicoplanin injection,thrombocytopenia |
| Abstract | Thrombocytopenia is a rare but dangerous adverse event when using vancomycin and teicoplanin. The objectives of this study were to evaluate the prevalence and related factors for vancomycin or teicoplanin injection associated thrombocytopenia. We conducted a cross-sectional study based on medical records of all patients aged 18 years and over, who were treated for at least 48 hours with vancomycin or teicoplanin injection at Thong Nhat hospital. Patients using oral vancomycin, or who had blood system disorders or platelet reduction associated with an original disease were excluded from this study. Thrombocytopenia was defined as a decrease in platelet count at least 25% from baseline and lower than 100 x 109/L. Thrombocytopenia was observed in 16.2% of patients received vancomycin and 21.9% of patients received teicoplanin (p = 0.292). |
